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Hybrid-Ultimate

filler lasts 2-5 years*

Ultra Firm Filler That Lasts 2-5 Years invented by Dr Sef.

Hybrid-ULTIMATE is our revolutionary dual effect hybrid injection. Which combines two powerful ingredients. Both ingredients are injected within the same treatment sessions to provide powerful, long lasting results.

PenisFill® Hyaluronic Acid Gel
Our proprietary blend of highly cross linked, high density gels.

PenisFill® PLLA
A potent collagen stimulating injection which is CE marked and obtained FDA approval for cosmetic use.

12,000mls

Filler Injected Annually

400+

Client Reviews

10+

Years of experience
01

What is PLLA?

PLLA (Poly-L-Lactic Acid) is an injectable medical synthetic polymer that has been used for the human body since 1960. Once injected, PLLA stimulates dermal fibroblasts to synthesis collagen, in a controlled manner. It has excellent bio-compatibility and is fully metabolised over a period of time. Such examples of its previous medical use include, one time infusion equipment , medical surgical sutures, drug delivery carriers, tissue engineering scaffolds, bone anchors, injectable micro capsules, microspheres, implants, elastomer material for organ support.

02

How do we use it?

PLLA is a potent, natural self-generation collagen stimulator. Once PLLA is injected into the penis, It will stimulate the growth of your own biologically semi-permanent penile tissue. This will increase the size of your penis. Penile fibroblasts lay down a matrix of thick, dense collagen fibres around the PLLA scaffold. 
After injection, overtime your body will fully metabolise the PLLA material and is excreted along the same pathway as lactic acid. With no harmful side effects to the human body, leaving behind a lattice of new penile collagen tissue which can last up to 2-5 years.* 

* J Am Acad Dermatol 2010;62:448-62
* Palm MD, Goldman MP. Patient satisfaction and duration of effect with PLLA: a review of the literature. J Drugs Dermatol. 2009;8(10 Suppl):s15-s20
* Individual results vary. Around 50% of the product will remain 2-5 years from date of implantation. Individual longevity of results vary between customers.

03

How does PLLA work?

Once injected, the PLLA forms a scaffold in the penile tissues. Dermal fibroblasts are stimulated and start to produce collagen fibres which interweave between the PLLA micro-spherical scaffolds. This process occurs as early as on the day of injection and collagen synthesis peaks at 2-3 month stage. The PLLA scaffold is naturally biodegraded over 6 months, leaving behind a dense network of collagen fibres which are biologically permanent and which can last between 2-5 years.*

* J Am Acad Dermatol 2010;62:448-62
* Individual results vary. Around 50% of the product will remain 2-5 years from date of implantation. Individual longevity of results vary between customers.

04

Why is it better than just Hyaluronic acid (HA) filler?

HA clearly has its advantages. Hence why we have performed thousands of PenisFill® premium HA successful treatments. However the main feedback from patients, is that the volume and size increase, is fantastic and met their expectations. However the treatment would be further optimised, if the results lasted longer and they didn’t need to come back once every 12-18 months for a top up.

They would also prefer if the volume gained by the filler felt more firm,hard and stiff. So that when erect, it feels like a rock hard penis. Therefore feeling more natural. 

PLLA produces a result which is more firmer than HA and the results lasts almost double the length of HA. With some studies reporting close to 5 years in longevity* 

This is because PLLA stimulates dermal fibroblasts to intensely lay down your own dense and tightly cross linked, natural collagen in your penis. This collagen is naturally permanent, and will take years to break down. And because it is your own collagen, which you grew yourself, which becomes part of you ( just like muscle growth and hypertrophy) nothing on the market will feel as natural as your own collagen being stimulated by PLLA injections. Collagen also has the highest natural viscoelastic properties, hence why it feels the hardest and firmest in the penis, compared with other fillers.

* J Am Acad Dermatol 2010;62:448-62
* Palm MD, Goldman MP. Patient satisfaction and duration of effect with PLLA: a review of the literature. J Drugs Dermatol. 2009;8(10 Suppl):s15-s20
* Individual results vary. Around 50% of the product will remain 2-5 years from date of implantation. Individual longevity of results vary between customers.

05

Why don’t I just have PLLA and no HA?

You can. However the volume (size) increase produced will not be as much as HA filler. Thus the layering of the two materials in one treatment produces the ultimate result. Ticking the boxes for size increase, longevity of results and optimal firmness. HA will always produce more volume than PLLA. However when combined with PLLA the results are very synergistic. PLLA provides further volume increase and crucially causes your result too last much longer and for the result to feel hard, firm and stiff. Providing a very natural and effective way to safely increase the size of your penis.

06

Is PLLA reversible?

Naturally overtime your body will completely excrete the medical PLLA. This process usually takes 3-6 months. However during this 3-6 months it will be stimulating collagen in the area it has been injected it. Once the collagen has formed, this is naturally semi- permanent. 

In the rare, but slightly increased event of small lumps and bumps of PLLA and collagen, we can smooth these out by blending in around it with additional HA / or reduce the lump with steroid and saline injections. HA has a marginally better safety profile, in that it can be fully reversed with a simple dissolvable injection.

07

How often do I need top ups?

We recommend a small maintenance top up within a few months of the initial treatment. This is to perfect the aesthetics of the penis. After this top up sessions are required every 2-5 years to maintain size. Results can hold and last for more than 2 years. With some results lasting up to 5 years.* 

* J Am Acad Dermatol 2010;62:448-62
* Palm MD, Goldman MP. Patient satisfaction and duration of effect with PLLA: a review of the literature. J Drugs Dermatol. 2009;8(10 Suppl):s15-s20
* Individual results vary. Around 50% of the product will remain 2-5 years from date of implantation. Individual longevity of results vary between customers.

08

What are the potential side effects and complications for PLLA injections?

The most common issues for all dermal fillers in general is an initial discomfort or temporary swelling and bruising which only lasts a few days. 

Not surprisingly, the most typical concerns regarding PLLA involves the results of the procedure. Problems such as, unevenness, lumps and nodules can occur but are easily managed. 

PLLA has a marginally increased risk compared to HA in the form of lumps and bumps. If the PLLA is not equally distributed along the penile shaft, there may be an area on the shaft where overstimulation of the tissue can occur, resulting in a small nodule. These are typically called Collagenoma’s. If theses do occur, the appearance of them can be improved with a subsequent treatment session to help blend or reduce the size of the nodule with a small steroid injection. But only time will fully reverse the nodule completely. ( 2-5 years). PLLA has a slightly increased risk compared to HA in that regard because with HA , if there are any nodules or lumps, they can be fully reversed. 

However the tradeoff is HA does not last as long as PLLA and does not feel as natural or as firm as PLLA collagen stimulation. 

Dr Sef uses the best optimal dilution protocols for safe administrations of PLLA .The rate of nodule formation is 0.15% with Dr Sef PenisFill® technique and protocol.*  

Another side affect is infection (very rare). If this does occur oral antibiotics are provided the infection typically clears up within 1 week. The PenisFill® technique is performed using aseptic techniques in state of the art sterile clinic rooms. Dr Sef is highly experienced and injected over 10,000 dermal fillers.

* Woerle B, Hanke CW, Sattler G. Poly-L-lactic acid: a temporary filler for soft tissue augmentation. J Drugs Dermatol. 2004;3(4):385-389
* Hamilton DG, Gauthier N, Robertson BF. Late-onset, recurrent facial nodules associated with injection of poly-L-lactic acid. Dermatol Surg. 2008;34(1):123-126; discussion 126 *Individual results vary 

09

How long do results last?

Over 2 years.* with published medical data suggesting results lasting between 2-5 years. 

* J Am Acad Dermatol 2010;62:448-62
* Palm MD, Goldman MP. Patient satisfaction and duration of effect with PLLA: a review of the literature. J Drugs Dermatol. 2009;8(10 Suppl):s15-s20
* Individual results vary. Around 50% of the product will remain 2-5 years from date of implantation. Individual longevity of results vary between customers.

10

What’s the difference between PLLA and PCL (eg. Ellanse)?

Both work in exactly the same manner; as collagen stimulators. We prefer PLLA as it has a much better safety profile. As we can control the dilution and injection technique much better with PLLA , resulting in a smooth, firm and long lasting result. PCL carries a further increased risk of nodule (lumps) formation.

11

Is it safe to inject both HA gel and PLLA at the same time?

Yes very safe.
In-fact the ingredients works synergistically with one another to produce greater size increase and a firmer result.

* Lorenc ZP, Daro-Kaftan E. Optimizing facial rejuvenation outcomes by combining poly-L-lactic acid, hyaluronic acid, calcium hydroxylapatite, and neurotoxins: two case studies.
* J Drugs Dermatol. 2014;13(2):191–195.Carruthers JD, Glogau RG, Blitzer A. Advances in facial rejuvenation: botulinum toxin type a, hyaluronic acid dermal fillers, and combination therapies–consensus recommendations.
* Plast Reconstr Surg. 2008;121(5 Suppl):5S-30S; quiz 31S-36S. doi: 10.1097/PRS.0b013e31816de8d0

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Dr Sef

Clinician

Dr Sef has performed over 10,000 successful medical aesthetic injections and Injectable procedures and is the only Doctor to perform the registered & licensed PenisFill® procedure. Read more about Dr Sef.

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